Functional analyses of mouse ASK, an activation subunit for Cdc7 kinase, using conditional ASK knockout ES cells

To ask or not to ask, that is the question

Appropriate Questions:  What are you looking for in a summer intern? (then be prepared to demonstrate how you fit those desired skills)  What has been your most interesting case/project in the past year?  What drew you to this employer/what was your path to this organization/firm?  I spoke with ______, the Michigan student who worked here two summers ago, and s/he said (fill in positive asp...

How to Ask for Permission

Application platforms provide applications with access to hardware (e.g., GPS and cameras) and personal data. Modern platforms use permission systems to protect access to these resources. The nature of these permission systems vary widely across platforms. Some platforms obtain user consent as part of installation, while others display runtime consent dialogs. We propose a set of guidelines to ...

A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells.

A novel human protein, ASK (activator of S phase kinase), was identified on the basis of its ability to bind to human Cdc7-related kinase (huCdc7). ASK forms an active kinase complex with huCdc7 that is capable of phosphorylating MCM2 protein. ASK appears to be the major activator of huCdc7, since immunodepletion of ASK protein from the extract is accompanied by the loss of huCdc7-dependent kin...

ASK: Active Spam Killer

We present Active Spam Killer (ASK), a program that attempts to validate unknown senders before allowing delivery of their message. Validation occurs by means of a challenge reply sent to senders who are not yet known to the system. Messages are kept in a queue pending confirmation until the sender replies to the challenge. Further messages coming from confirmed senders are delivered immediatel...

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